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Osteogenic Evaluation of Glutaraldehyde Crosslinked Gelatin Composite with Fetal Rat Calvarial Culture Model by Hwa‐Chang Liu; Chun‐Hsu Yao; Jui‐Sheng Sun; Chun‐Jean Lee; Chin‐Wang Huang; Feng‐Huei Lin is a Medicine article available to read on EtoBox.
What is Osteogenic Evaluation of Glutaraldehyde Crosslinked Gelatin Composite with Fetal Rat Calvarial Culture Model about?
Abstract: The cytotoxicity of the synthetic bone substitute composed of tricalcium phosphate and glutaraldehyde crosslinked gelatin (GTG) were evaluated by osteoblast cell culture. In a previous study, the GTG composites were soaked in distilled water for 1, 2, 4, 7, 14, 28, and 42 days, and then the solutions (or extracts) were cocultured with osteoblasts to evaluate the cytotoxicity of GTG composites by alive cell counting. In this study, the extracts were cocultured with the osteoblasts; thereafter, the concentration of transforming growth factor‐β (TGF‐β~1~) and prostaglandin E~2~ (PGE~2~) in the medium was analyzed to strictly reflect the biological effects of GTG composites on the growth of osteoblasts. In order to investigate the osteoconductive potential of the GTG composites on new bone formation in a relative short term, a model of neonatal rat calvarial organ culture was designed prior to animal experiments. Three experimental materials of 4, 8, and 12% GTG composites were evaluated by fetal rat calvarial organ culture for their ability for bone regeneration. Deproteinized bovine and porcine cancellous bone matrixes were used as the controlled materials. All the organ cu
Who reads Osteogenic Evaluation of Glutaraldehyde Crosslinked Gelatin Composite with Fetal Rat Calvarial Culture Model?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hwa‐Chang Liu; Chun‐Hsu Yao; Jui‐Sheng Sun; Chun‐Jean Lee; Chin‐Wang Huang; Feng‐Huei Lin
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0160-564X)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)