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Perinatal Factors and the Risk of Testicular Germ Cell Tumors by Michael B. Cook; Barry I. Graubard; Mark V. Rubertone; Ralph L. Erickson; Katherine A. McGlynn is a Medicine article available to read on EtoBox.

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## Abstract Testicular germ cell tumors (TGCT) are the most common cancer among young men in the United States and Western Europe. Prior evidence suggests that TGCT may arise in perinatal life, although few risk factors have yet been identified. To study the etiology of TGCT, the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) case‐control study enrolled participants and their mothers between 2002 and 2005. Five hundred twenty‐seven mothers of cases and 561 mothers of controls provided information on perinatal variables. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (95%CI) associated with the candidate risk factors. Analyses were conducted for all TGCT together and for each histologic subgroup (seminoma and nonseminoma) separately. Young maternal age (<20 __vs.__ 20–29 years, OR = 1.51, 95%CI: 1.09–2.10), young paternal age (<25 __vs.__ 25–29 years, OR = 1.45, 95%CI: 1.08–1.94), maternal parity (3 __vs.__ 1, OR = 0.63, 95%CI: 0.44–0.90) and breech birth (OR = 1.92, 95%CI: 1.03–3.56) were associated with risk of TGCT. For seminoma, young maternal age (<20 __vs.__ 20–29 years, OR = 1.67, 95%CI: 1.10–2.54), y

Who reads Perinatal Factors and the Risk of Testicular Germ Cell Tumors?

Author

Michael B. Cook; Barry I. Graubard; Mark V. Rubertone; Ralph L. Erickson; Katherine A. McGlynn

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2008

Language

EN

Field

Medicine (Health Sciences)