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Computational proteomics analysis of HIV‐1 protease interactome by Aleksejs Kontijevskis; Jarl E. S. Wikberg; Jan Komorowski is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Computational proteomics analysis of HIV‐1 protease interactome about?

## Abstract HIV‐1 protease is a small homodimeric enzyme that ensures maturation of HIV virions by cleaving the viral precursor Gag and Gag‐Pol polyproteins into structural and functional elements. The cleavage sites in the viral polyproteins share neither sequence homology nor binding motif and the specificity of the HIV‐1 protease is therefore only partially understood. Using an extensive data set collected from 16 years of HIV proteome research we have here created a general and predictive rule‐based model for HIV‐1 protease specificity based on rough sets. We demonstrate that HIV‐1 protease specificity is much more complex than previously anticipated, which cannot be defined based solely on the amino acids at the substrate's scissile bond or by any other single substrate amino acid position only. Our results show that the combination of at least three particular amino acids is needed in the substrate for a cleavage event to occur. Only by combining and analyzing massive amounts of HIV proteome data it was possible to discover these novel and general patterns of physico‐chemical substrate cleavage determinants. Our study is an example how computational biology methods can advanc

Who reads Computational proteomics analysis of HIV‐1 protease interactome?

Author

Aleksejs Kontijevskis; Jarl E. S. Wikberg; Jan Komorowski

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0887-3585)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)