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Can I read Concentrations of Interferon‐γ‐Induced Protein‐10 (IP‐10), an Antiangiogenic Substance, are Decreased in Peritoneal Fluid of Women with Advanced Endometriosis on EtoBox?
Concentrations of Interferon‐γ‐Induced Protein‐10 (IP‐10), an Antiangiogenic Substance, are Decreased in Peritoneal Fluid of Women with Advanced Endometriosis by Osamu Yoshino; Yutaka Osuga; Kaori Koga; Yasushi Hirota; Osamu Tsutsumi; Tetsu Yano; Yutaka Morita; Mikio Momoeda; Toshihiro Fujiwara; Koji Kugu; Yuji Taketani is a Medicine article available to read on EtoBox.
What is Concentrations of Interferon‐γ‐Induced Protein‐10 (IP‐10), an Antiangiogenic Substance, are Decreased in Peritoneal Fluid of Women with Advanced Endometriosis about?
**Problem:** To assess whether interferon‐γ‐induced protein‐10 (IP‐10), a chemokine that has antiangiogenic activities, may be involved in the pathogenesis of endometriosis. **Method of Study:** A total of 120 patients undergoing laparoscopy for pain and/or infertility were recruited, and peritoneal fluid (PF) and bone marrow derived cells in PF were collected. Concentrations of IP‐10 in PF were measured with a specific enzyme‐linked immunosorbent assay. Expression of IP‐10 and IP‐10 receptor, CXCR3, in bone marrow derived cells in PF, peritoneum and endometriotic cells was analyzed by reverse transcription‐polymerase chain reaction. **Results:** All of the PF samples examined contained detectable concentrations of IP‐10. In women with advanced stages of endometriosis, IP‐10 concentrations in PF were significantly lower than those of women in early stages (__P__ = 0.02). The IP‐10 concentrations in women with advanced endometriosis also appeared to be lower than those without endometriosis although the difference was statistically marginal (__P__ = 0.06). The expression of both IP‐10 and CXCR3 was clearly detected in the bone marrow derived cells in PF, peritoneum and endometriotic
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- Author
- Osamu Yoshino; Yutaka Osuga; Kaori Koga; Yasushi Hirota; Osamu Tsutsumi; Tetsu Yano; Yutaka Morita; Mikio Momoeda; Toshihiro Fujiwara; Koji Kugu; Yuji Taketani
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 8755-8920)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)