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What is FISH Technique: Principles and Procedure about?
Fluorescence in situ hybridization (FISH) is a technique that uses fluorescent probes that bind to only parts of the genome to identify specific gene sequences or chromosomal abnormalities in cells and tissue samples. FISH involves denaturing chromosomes and DNA probes, hybridizing them, staining with fluorescent markers, and examining under a microscope. It can detect genetic changes like gene fusions, extra or missing chromosomes, and has applications in research, diagnosis of genetic diseases, and cancer
- Author
- Reuben Vijaysekar
- Language
- EN