Can I read Reconsidering the Role of Protein Glycation in Disease on EtoBox?

Reconsidering the Role of Protein Glycation in Disease by Marissa N. Trujillo & James J. Galligan is a book available to read on EtoBox.

What is Reconsidering the Role of Protein Glycation in Disease about?

Nature Chemical Biology, doi:10.1038/s41589-023-01382-7Protein glycation has long-been considered In this Comment, we present an emerging paradigm that supports a hormetic role for protein glycation, extending beyond a toxic consequence of carbohydrate its designation as a simple measure of ‘sugar toxicity’. This field has metabolism. Yet recent evidence demonstrates drawn notable parallels to that of protein oxidation, which was long believed to serve as a measure of oxidative stress and protein damage8. tight regulation for these non-enzymatic It was not until appropriate study designs were established that reactive post-translational modifcations, pointing to a oxygen species (ROS) gained an appreciated homeostatic role in the broader role in cell biology rather than simply regulation of numerous cellular processes, including metabolic flux and transcriptional responses to cellular redox status8. Here, we opine serving as a biomarker for toxicity.that glycation should be evaluated in the same vein as other canonical PTMs, including protein oxidation, in which dose and context should Post-translational modifications (PTMs) provide a rapid response to be taken into consideration.r

Author

Marissa N. Trujillo & James J. Galligan

Publisher

x

Published

2023

Language

EN