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Can I read Acid-Catalyzed Oxy-aminomethylation of Styrenes on EtoBox?
Acid-Catalyzed Oxy-aminomethylation of Styrenes by Marian Guillén; Sensheng Liu; C. David Díaz-Oviedo; Martin Klussmann; Benjamin List is a Chemistry article available to read on EtoBox.
What is Acid-Catalyzed Oxy-aminomethylation of Styrenes about?
We report a strong Brønsted acid-catalyzed three-component oxy-aminomethylation of styrenes with __sym__-trioxane and sulfonamides or carbamates. This transformation provides a variety of 1,3-oxazinanes in moderate to good yields under mild reaction conditions. The obtained heterocycles can be readily transformed into the corresponding 1,3-amino alcohols, which are useful building blocks for the synthesis of pharmaceutically relevant molecules. Mechanistic studies suggest the intermediacy of an in situ formed 1,3,5-dioxazinane and a subsequent reaction with the olefin.
Who reads Acid-Catalyzed Oxy-aminomethylation of Styrenes?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Marian Guillén; Sensheng Liu; C. David Díaz-Oviedo; Martin Klussmann; Benjamin List
- Publisher
- American Chemical Society
- Published
- 2024
- Language
- EN
- Field
- Chemistry (Physical Sciences)