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FXYD6 promotes thermal nociception by regulating TRPV1 by Luo, Hao (author);Cai, Bing (author);Pan, Jing (author);Shi, Hai-Xiang (author);Wang, Kai-Kai (author);Zhong, Yan-Qing (author);Lu, Ying-Jin (author);Bao, Lan (author);Zhang, Xu (author);Li, Kai-Cheng (author) is a Medicine article available to read on EtoBox.

What is FXYD6 promotes thermal nociception by regulating TRPV1 about?

FXYD6, an unnecessary auxiliary subunit of Na^+^,K^+^-ATPase, is expressed in the nervous system. However, its functions remain largely unclear. In the present study, we find that FXYD6 is involved in the thermal nociception. FXYD6 was mainly expressed in small-diameter DRG neurons expressing transient receptor potential channel V1 (TRPV1). In the __SNS-Cre__/__Fxyd6^F/F^__ mice, loss of FXYD6 in these sensory neurons impaired the behavioral responses to noxious heat stimulus and intraplantar injection of capsaicin. The capsaicin-induced and TRPV1-mediated currents were decreased in the FXYD6–deficient DRG neurons. Heterologous expression of FXYD6 could increase the TRPV1 capsaicin-sensitive currents in HEK293 cells. Furthermore, we found that the negatively charged PGDEE motif in C-terminal of FXYD6 is required for the FXYD6/TRPV1 interaction and FXYD6-mediated enhancement of TRPV1. Disrupting the FXYD6/TRPV1 interaction with the TAT-PGDEE peptide could elevate the threshold of thermal nociception. Therefore, FXYD6 maintains the thermal nociception via interacting with TRPV1 channel in nociceptors.

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Author

Luo, Hao (author);Cai, Bing (author);Pan, Jing (author);Shi, Hai-Xiang (author);Wang, Kai-Kai (author);Zhong, Yan-Qing (author);Lu, Ying-Jin (author);Bao, Lan (author);Zhang, Xu (author);Li, Kai-Cheng (author)

Publisher

SAGE Publications

Published

2021

Language

EN

Field

Medicine (Health Sciences)