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Clinical Perspectives Into the Use of Thalidomide for Central Nervous System Tuberculosis by S. Keddie; V. Bharambe; A. Jayakumar; A. Shah; V. Sanchez; A. Adams; S. Gnanapavan is a Medicine article available to read on EtoBox.

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## Background and purpose: Central nervous system (cns) tuberculosis (tb) accounts for over 4% of all tb notifications in the uk and causes death or significant disability in over half of those affected. tumour necrosis factor alpha is a critical cytokine involved in the neuropathogenesis of cns tb. thalidomide has been trialled in cns tb due to its immunomodulatory and immune reconstitution effects through the inhibition of tumour necrosis factor alpha. despite animal models demonstrating dramatic improvement in survival, studies in paediatric patients have been associated with higher levels of mortality. the effects of thalidomide have not yet been studied in adults with cns tb. this narrative case series guides clinicians through a range of cns tb clinical cases seen in a large london teaching hospital, serving a region with a high incidence of tb (32 per 100 000) with 55% of tb cases manifesting as extrapulmonary disease. we aimed to illustrate our experiences of using thalidomide to treat a range of severe cns tb complications. ## Methods: Five inpatients at the royal london hospital, london, uk treated with thalidomide in addition to standard tb treatment are described in det

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Author

S. Keddie; V. Bharambe; A. Jayakumar; A. Shah; V. Sanchez; A. Adams; S. Gnanapavan

Published

2018

Language

EN

Field

Medicine (Health Sciences)