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Can I read Brain Metabolism of Progesterone, Coping Behaviour and Emotional Reactivity in Male Rats from Two Psychogenetically Selected Lines on EtoBox?
Brain Metabolism of Progesterone, Coping Behaviour and Emotional Reactivity in Male Rats from Two Psychogenetically Selected Lines by Th. Steimer; P. Driscoll; P. E. Schulz is a Neuroscience article available to read on EtoBox.
What is Brain Metabolism of Progesterone, Coping Behaviour and Emotional Reactivity in Male Rats from Two Psychogenetically Selected Lines about?
Brain metabolites of progesterone such as tetrahydroprogesterone (THP) act on GABA~A~ receptors and have anxiolytic properties. The formation of THP and its 5α‐reduced precursor, dihydroprogestrone (DHP) was measured __in vitro__ in various microdissected brain areas obtained from males of two psychogenetically selected rat lines, i.e. the Roman High‐(RHA/Verh) and Low‐(RLA/Verh) Avoidance rats, which are known to differ in emotional reactivity and/or anxiety. The behavioural and neuroendocrine responses of these rats were also measured following exposure to a novel environment in two different test situations. The formation of DHP and THP was found to be significantly higher in the frontal cortex (FCX), and DHP in the bed nucleus of the stria terminalis (BST), of the hypoemotional RHA/Verh rats. In addition, enzymatic activity in the FCX was found to be inversely correlated with behavioural measures of anxiety. These results suggest that individual, possibly genetically‐determined differences in brain production of endogenous anxiolytics derived from progesterone may account at least in part for the behavioural differences characterizing these two lines, and provide further eviden
Who reads Brain Metabolism of Progesterone, Coping Behaviour and Emotional Reactivity in Male Rats from Two Psychogenetically Selected Lines?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Th. Steimer; P. Driscoll; P. E. Schulz
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-8194)
- Published
- 1997
- Language
- EN
- Field
- Neuroscience (Life Sciences)