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Distribution of Prosaposin-like Immunoreactivity in Rat Brain by Keiji Kondoh; Akira Sano; Yasuo Kakimoto; Seiji Matsuda; Masahiro Sakanaka is a Neuroscience article available to read on EtoBox.

What is Distribution of Prosaposin-like Immunoreactivity in Rat Brain about?

Prosaposin is the precursor for saposins A, B, C, and D, which are small lysosomal proteins required for the hydrolysis of sphingolipids by specific lysosomal hydrolases. With a monospecific anti-saposin C antibody, which cross-reacts with prosaposin but not with saposin A, B, or D, the present immunoblot experiments showed that the rat brain expresses an unprocessed -72 kDa protein (possibly prosaposin) and little saposin C. Regional analysis demonstrated that prosaposin is abundant in the brainstem, hypothalamus, cerebellum, striatum, and hippocampus, and less abundant in the cerebral cortex. Consistent with this finding, prosaposinlike immunoreactive neurons and fibers as revealed by immunohistochemistry were observed frequently in subcortical regions. The medial septum, diagonal bands, basal nucleus of Meynert, ventral striatum, medial habenular nucleus, and motor nuclei of cranial nerve had significant numbers of immunoreactive neurons. There were also nerve fibers with prosaposinlike immunoreactivity in several projection fields of the above nuclei. Other brain areas that contained prosaposin-like immunoreactive neurons and/or processes were: several brain nuclei (nucleus cau

Who reads Distribution of Prosaposin-like Immunoreactivity in Rat Brain?

Author

Keiji Kondoh; Akira Sano; Yasuo Kakimoto; Seiji Matsuda; Masahiro Sakanaka

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

1993

Language

EN

Field

Neuroscience (Life Sciences)