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Metabolic Imaging of Tumors Using Intrinsic and Extrinsic Fluorescent Markers by Zhihong Zhang; Hui Li; Qian Liu; Lanlan Zhou; Min Zhang; Qingming Luo; Jerry Glickson; Britton Chance; Gang Zheng is a Engineering article available to read on EtoBox.

What is Metabolic Imaging of Tumors Using Intrinsic and Extrinsic Fluorescent Markers about?

One of the biochemical "hallmarks" of malignancy is enhanced tumor glycolysis, which is primary due to the overexpression of glucose transporters (GLUTs) and the increased activity of mitochondria-bound hexokinase in tumors. Easy methods for assessing glucose utilization in vitro and in vivo should find widespread application in biological and biomedical studies, as illustrated by the adoption of FDG PET imaging in medicine. We have recently synthesized a new NIR fluorescent pyropheophorbide conjugate of 2-deoxyglucose (2DG), Pyro-2DG, as a GLUT-targeted photosensitizer. In this study, we have evaluated the in vivo uptake of Pyro-2DG and found that Pyro-2DG selectively accumulated in two tumor models, 9L glioma in the rat and c-MYC-induced mammary tumor in the mouse, compared to surrounding normal muscle tissues at a ratio of about 10:1. By simultaneously performing redox ratio and fluorescence imaging, a high degree of correlation between the PN/(Fp+PN) redox ratio, where PN denotes reduced pyridine nucleotides (NADH) and Fp denotes oxidized flavoproteins, and the Pyro-2DG uptake was found in both murine tumor models, indicating that Pyro-2DG could serve as an extrinsic NIR fluore

Who reads Metabolic Imaging of Tumors Using Intrinsic and Extrinsic Fluorescent Markers?

Author

Zhihong Zhang; Hui Li; Qian Liu; Lanlan Zhou; Min Zhang; Qingming Luo; Jerry Glickson; Britton Chance; Gang Zheng

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0956-5663)

Published

2004

Language

EN

Field

Engineering (Physical Sciences)