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Complement dysregulation is associated with severe COVID-19 illness by Jia Yu; Gloria F. Gerber; Hang Chen; Xuan Yuan; Shruti Chaturvedi; Evan M. Braunstein; Robert A. Brodsky is a Medicine article available to read on EtoBox.
What is Complement dysregulation is associated with severe COVID-19 illness about?
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may manifest as thrombosis, stroke, renal failure, myocardial infarction, and thrombocytopenia, reminiscent of other complement- mediated diseases. Multiple clinical and preclinical studies have implicated complement in the pathogenesis of COVID-19 illness. We previously found that the SARS-CoV-2 spike protein activates the alternative pathway of complement (APC) __in vitro__ through interfering with the function of complement factor H, a key negative regulator of APC. Here, we demonstrated that serum from 58 COVID-19 patients (32 patients with minimal oxygen requirement, 7 on high flow oxygen, 17 requiring mechanical ventilation and 2 deaths) can induce complementmediated cell death in a functional assay (the modified Ham test) and increase membrane attack complex (C5b-9) deposition on the cell surface. A positive modified Ham assay (>20% cell-killing) was present in 41.2% COVID-19 patients requiring intubation (n=7/17) and only 6.3% in COVID-19 patients requiring minimal oxygen support (n=2/32). C5 and factor D inhibition effectively mitigated the complement amplification induced by COVID-19 patient serum. Increased ser
Who reads Complement dysregulation is associated with severe COVID-19 illness?
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- Author
- Jia Yu; Gloria F. Gerber; Hang Chen; Xuan Yuan; Shruti Chaturvedi; Evan M. Braunstein; Robert A. Brodsky
- Publisher
- Fondazione Ferrata Storti
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)