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No clinical utility of common polymorphisms in IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 genes previously associated with insulin resistance in overweight children from Romania and Moldova by Adela Chirita-Emandi; Diana Munteanu; Nicoleta Andreescu; Paul Tutac; Corina Paul; Iulian Puiu Velea; Agneta Maria Pusztai; Victoria Hlistun; Chiril Boiciuc; Victoria Sacara; Lorina Vudu; Natalia Usurelu; Maria Puiu is a Medicine article available to read on EtoBox.

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Background: Previous genome-wide association studies (GWAS) identified IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 as candidate genes for insulin resistance and type 2 diabetes (T2D). We investigated the associations of these previously reported common variants in these genes with insulin resistance in overweight children from Romania and Moldova. Methods: Six single nucleotide polymorphisms (SNPs), IGF1 (rs35767), IRS1 (rs2943634), GCKR (rs780094), PPARG (rs1801282), GCK1 (rs1799884) and KCTD15 (rs29941), were genotyped in 100 overweight children along with clinical and metabolic parameters. Homeostatic model assessment of insulin resistance (HOMA-IR) above 3.4 (defining insulin resistance) was used as the outcome. Results: Children differed in insulin resistance status despite having similar body mass index (BMI) standard deviation scores (SDS) (World Health Organization, [WHO] reference). The identified predictors for altered insulin metabolism were higher cholesterol levels, higher diastolic blood pressure and higher waist-to-hip-ratio (as a marker for increased abdominal fat). None of the SNPs showed significant association with increase in the risk for insulin resistance in child

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Author

Adela Chirita-Emandi; Diana Munteanu; Nicoleta Andreescu; Paul Tutac; Corina Paul; Iulian Puiu Velea; Agneta Maria Pusztai; Victoria Hlistun; Chiril Boiciuc; Victoria Sacara; Lorina Vudu; Natalia Usurelu; Maria Puiu

Publisher

Walter de Gruyter GmbH

Published

2019

Language

EN

Field

Medicine (Health Sciences)