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Urinary carnitine excretion increases during experimental vitamin C depletion of healthy men by Robert A. Jacob; Frederick S. Pianalto is a Medicine article available to read on EtoBox.

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The requirement for ascorbic acid in the biosynthesis of carnitine may provide an explanation for the muscle weakness of scurvy and the basis for a functional measure of ascorbate status. To determine the relationship between vitamin C nutriture and camitine status in humans, we measured total plasma and urinary carnitine concentrations in samples taken from two vitamin C depletion/repletion studies performed with healthy men on a metabolic unit. Throughout the 13.week studies, the groups of nine and eight men consumed a vitamin C-deficient diet that was supplemented with ascorbic acid to provide varying intakes of the vitamin from 5 to 605 mg/day. The subjects attained a state of moderate, nonscorbutic vitamin C deficiency during periods of low vitamin C intake, as indicated by plasma and leukocyte ascorbate concentrations. Plasma carnitine and triglyceride concentrations were not afSected by the various vitamin C intakes; however, urinary carnitine excretion was increased during periods of ascorbate deficiency and was inversely related to leukocyte ascorbate concentrations. Vitamin C deficiency increases carnitine excretion, but the increased carnitine loss has no effect on carni

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Author

Robert A. Jacob; Frederick S. Pianalto

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0955-2863)

Published

1997

Language

EN

Field

Medicine (Health Sciences)