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What is Fentanyl about?

This study investigates the distinct roles of µ-opioid receptor (µOR) ensembles in mediating positive and negative reinforcement associated with fentanyl addiction. It identifies that disinhibition of dopamine neurons in the ventral tegmental area (VTA) leads to positive reinforcement, while µORs in the central amygdala (CeA) are responsible for negative reinforcement during withdrawal. These findings provide insights into the neural circuits involved in fentanyl addiction and suggest potential targets for

Author

leegw090917

Language

EN