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Thiabendazole-induced Cytogenetic Abnormalities in Mouse Oocytes by John B. Mailhes; Daniel Young; Marilyn J. Aardema; S. N. London is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Thiabendazole-induced Cytogenetic Abnormalities in Mouse Oocytes about?

Of the various classes of human genetic disorders, Superovulated ICR female mice were administered aneuploidy is the most prevalent. Besides its associ-0, 50, 100, or 150 mg/kg TBZ by intraperitoneal ation with maternal age and its predominant origin injection. The frequencies and percentages of hyduring maternal meiosis I, little is known about the perploid oocytes were 0/472 (0), 2/410 (0.5), 6/ etiology of aneuploidy. Although various classes of 478 (1.3), and 3/427 (0.7) for control, 50, 100, chemicals have been shown to induce aneuploidy and 150 mg/kg TBZ, respectively. The difference in experimental systems, there is no definitive evi-between controls and the 100 mg/kg dose was dence for the role of chemically induced aneuploidy statistically significant. Also, the proportions of ovuand adverse human health effects, particularly germ latory mice and the number of oocytes collected cell effects. Thus, it is important to understand the per ovulatory female were reduced in the TBZ groups potential of chemicals for inducing aneuploidy in relative to controls. Based on these results, we congerm cells. There are conflicting data in the litera-clude that TBZ induces a small, but sig

Who reads Thiabendazole-induced Cytogenetic Abnormalities in Mouse Oocytes?

Author

John B. Mailhes; Daniel Young; Marilyn J. Aardema; S. N. London

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0893-6692)

Published

1997

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)