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1.4T study of proton magnetic relaxation rates, iron concentrations, and plaque burden in Alzheimer's disease and control postmortem brain tissue by Michael J. House; Timothy G. St. Pierre; Catriona McLean is a Medicine article available to read on EtoBox.

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## Abstract We measured proton magnetic longitudinal (__R__~1~) and transverse (__R__~2~) relaxation rates at 1.4T, iron concentrations, water contents, and amyloid plaque densities in postmortem brain tissue samples from three Alzheimer's disease (AD), two possible AD, and five control subjects. Iron concentrations and __R__~1~ were significantly higher in the temporal cortex region of our AD group compared to the controls. Frequency analyses showed that the observed trends of higher iron, __R__~1~, and __R__~2~ in AD gray matter regions were statistically significant. Simple regression models indicated that for AD and control gray matter the iron concentrations and water contents have significant linear correlations with __R__~1~ and __R__~2~. Multiple regression models based on iron concentrations and water contents were highly significant for all groups and tissue types and suggested that the effects of iron become more important in determining __R__~1~ and __R__~2~ in the AD samples. At 1.4T __R__~1~ and __R__~2~ are strongly affected by water content and to a lesser extent by variations in iron concentrations. The AD plaque density did not correlate with iron concentrations,

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Author

Michael J. House; Timothy G. St. Pierre; Catriona McLean

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2008

Language

EN

Field

Medicine (Health Sciences)