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Can I read Palliative isolated limb perfusion for advanced limb disease in stage IV melanoma patients on EtoBox?
Palliative isolated limb perfusion for advanced limb disease in stage IV melanoma patients by R.B. Takkenberg; B.C. Vrouenraets; A.N. van Geel; O.E. Nieweg; E.M. Noorda; A.M.M. Eggermont; B.B.R. Kroon is a Medicine article available to read on EtoBox.
What is Palliative isolated limb perfusion for advanced limb disease in stage IV melanoma patients about?
Introduction: Two to three percent of the patients with extremity melanoma develop in-transit metastases in the course of their disease. When local treatments fail, isolated limb perfusion (ILP) is a reasonable option, but is generally only applied to patients without evidence of distant metastases. We assessed the value of ILP in stage IV melanoma patients with symptomatic unresectable limb melanoma at our institutions. Patients and Methods: A computerized database, containing all patient, tumor, ILP, and follow-up data of 505 ILPs performed in 451 patients between 1978 and 2001, allowed the selection of eight (1.8%) stage IV patients who underwent a palliative ILP for unresectable melanoma lesions on the limbs. All patients had high tumor burden limb disease, according to the combined Fraker and Rossi criteria. Results: The overall tumor response rate was 88%, with 13% complete and 75% partial response rates. One patient did not respond to ILP. Three partial responding patients attained a complete remission (CR) after excision of the remaining limb lesions. The median duration of hospital stay was 12 days and acute regional toxicity was mild with slight erythema and edema in six
Who reads Palliative isolated limb perfusion for advanced limb disease in stage IV melanoma patients?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- R.B. Takkenberg; B.C. Vrouenraets; A.N. van Geel; O.E. Nieweg; E.M. Noorda; A.M.M. Eggermont; B.B.R. Kroon
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-4790)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)