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Loop diuretics are potent diuretics used for rapid edema mobilization, acting primarily on the thick ascending limb of the loop of Henle by inhibiting the Na⁺/K⁺/2Cl⁻ cotransporter. Commonly used loop diuretics include furosemide, bumetanide, torsemide, and ethacrynic acid, each with varying bioavailability and potency. They are effective in treating conditions like congestive heart failure and pulmonary edema but can cause adverse effects such as electrolyte disturbances and ototoxicity.
- Author
- Siddharth Sahai
- Language
- EN