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Clinical Role of Human Leukocyte Antigen in Health and Disease by Y. M. Mosaad is a Immunology and Microbiology article available to read on EtoBox.
What is Clinical Role of Human Leukocyte Antigen in Health and Disease about?
## Abstract Most of the genes in the major histocompatibility complex (__MHC__) region express high polymorphism that is fundamental for their function. The most important function of human leukocyte antigen (HLA) molecule is in the induction, regulation of immune responses and the selection of the T cell repertoire. A clinician's attention is normally drawn to a system only when it malfunctions. The HLA system is no exception in this regard, but in contrast to other systems, it also arouses interest when it functions well – too well, in fact. Population studies carried out over the last several decades have identified a long list of human diseases that are significantly more common among individuals that carry particular __HLA__ alleles including inflammatory, autoimmune and malignant disorders. HLA‐disease association is the name of this phenomenon, and the mechanism underlying is still a subject of hot debate. Social behaviours are affected by __HLA__ genes and preference for __HLA__ disparate mates may provide ‘good genes’ for an individual's offspring. Also, certain __HLA__ genes may be associated with shorter life and others with longer lifespan, but the effects depend both o
Who reads Clinical Role of Human Leukocyte Antigen in Health and Disease?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Y. M. Mosaad
- Publisher
- Wiley
- Published
- 2015
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)