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PPAR Gamma and Hepatic Stellate Cells by Saswati Hazra; Takeo Miyahara; Richard A Rippe; Hidekazu Tsukamoto is a Medicine article available to read on EtoBox.

What is PPAR Gamma and Hepatic Stellate Cells about?

Activation of Hepatic stellate cells (HSC) in fibrogenesis involves distinct morphological and biochemical changes. This activation requires the coordinated changes in activity of several transcription factors. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one such factor whose activity is decreased in activated HSC. PPAR gamma ligands suppress several markers of HSC activation such as expression of collagen and alpha smooth muscle actin (alpha-SMA), cell proliferation and migration. Expression of PPAR gamma, per se, also inhibits HSC activation. These findings support the role of PPAR gamma in reversion of activated HSC toward their quiescent state.

Who reads PPAR Gamma and Hepatic Stellate Cells?

Author

Saswati Hazra; Takeo Miyahara; Richard A Rippe; Hidekazu Tsukamoto

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, c2002-2012.; Springer Science and Business Media LLC (ISSN 1476-5926)

Published

2004

Language

EN

Field

Medicine (Health Sciences)