Can I read Dissolving microneedles for effective and painless intradermal drug delivery in various skin conditions: A systematic review on EtoBox?
Dissolving microneedles for effective and painless intradermal drug delivery in various skin conditions: A systematic review by Ignace De Decker; Thomas Logé; Henk Hoeksema; Marijn M. Speeckaert; Phillip Blondeel; Stan Monstrey; Karel E. Y. Claes is a Medicine article available to read on EtoBox.
What is Dissolving microneedles for effective and painless intradermal drug delivery in various skin conditions: A systematic review about?
## Abstract Intra‐ and transdermal administration of substances via percutaneous injection is effective but considered painful, and inconvenient in addition to bringing forth biohazardous waste material. In contrast to injection, topical drug application, which includes ointments, creams and lotions, increases the local drug load. Moreover, it has reduced side effects compared to systemic administration. However, the epidermis poses a barrier to high molecular weight substances, limiting the delivery efficiency. Dissolving microneedles (DMN) are hydrophilic, mostly polymer‐based constructs that are capable of skin penetration and were developed to provide painless and direct dermal drug delivery. This systematic review provides a comprehensive overview of the available clinical evidence for the use of DMN to treat various skin conditions. According to the PRISMA statement, a systematic search for articles on the use of DMN for dermatological indications was conducted on three different databases (Pubmed, Embase, and the Cochrane library). Only human clinical trials were considered. Qualitative assessment was done by two separate reviewers using the Cochrane risk of bias (RoB 2) and
Who reads Dissolving microneedles for effective and painless intradermal drug delivery in various skin conditions: A systematic review?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ignace De Decker; Thomas Logé; Henk Hoeksema; Marijn M. Speeckaert; Phillip Blondeel; Stan Monstrey; Karel E. Y. Claes
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)