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1. A high-fat diet (HFD) causes widespread remodeling of the liver circadian clock by reprogramming metabolic pathways and circadian gene expression. 2. HFD disrupts normal circadian oscillations of many transcripts and metabolites and also causes de novo circadian oscillations of numerous other transcripts and metabolites. 3. This reprogramming involves both impairment of CLOCK:BMAL1 chromatin recruitment and induction of oscillations in PPARg-mediated transcriptional pathways of non-cycling genes. 4. T
- Author
- Jefferson Moreno
- Language
- EN