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Can I read Deficiency of miRNA-149-3p shaped gut microbiota and enhanced dextran sulfate sodium-induced colitis on EtoBox?
Deficiency of miRNA-149-3p shaped gut microbiota and enhanced dextran sulfate sodium-induced colitis by Qingqing Feng; Yuanqiang Li; Hongli Zhang; Ziwei Wang; Xiaobo Nie; Denglin Yao; Lu Han; Wei-Dong Chen; Yan-Dong Wang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Deficiency of miRNA-149-3p shaped gut microbiota and enhanced dextran sulfate sodium-induced colitis about?
Genetic predisposition and disruption of host gut microbiota and immune system can result in inflammatory bowel disease (IBD). Here, we show that miRNA-149-5p (miR-149-5p) and miRNA-149-3p (miR-149-3p) play crucial roles in IBD. Mice lacking miR-149-3p were considerably more susceptible to dextran sulfate sodium (DSS)-induced colitis than wild-type (WT) mice, accompanied by more serious inflammatory symptoms and increased gene expression of certain inflammatory cytokines. Both miR-149-5p and miR-149-3p suppressed colon inflammatory response __in vitro__ and __in vivo__. Furthermore, we found significant differences in the composition of the gut microbiota between WT and miR-149-3p^−/−^ mice by 16S rRNA sequencing. Co-housing endowed susceptibility to WT mice against DSS-induced colitis compared with the WT control group. However, susceptibility of miR-149-3p^−/−^ mice against DSS-induced colitis was still present after antibiotic treatment. These findings suggest that the deletion of miR-149-3p altered gut microbiota and influenced pathogenesis of intestinal inflammation, but sensitivity of miR-149-3p^−/−^ mice to DSS-induced colitis is not conferred by microbiota. In addition, we
Who reads Deficiency of miRNA-149-3p shaped gut microbiota and enhanced dextran sulfate sodium-induced colitis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Qingqing Feng; Yuanqiang Li; Hongli Zhang; Ziwei Wang; Xiaobo Nie; Denglin Yao; Lu Han; Wei-Dong Chen; Yan-Dong Wang
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)