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Can I read Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: Heparin prevents and treats liver damage on EtoBox?
Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: Heparin prevents and treats liver damage by Sujith V. W. Weerasinghe; David S. Moons; Peter J. Altshuler; Yatrik M. Shah; M. Bishr Omary is a Medicine article available to read on EtoBox.
What is Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: Heparin prevents and treats liver damage about?
Fas ligand (FasL)-mediated hepatocyte apoptosis occurs in the context of acute liver injury that can be accompanied by intravascular coagulation (IC). We tested the hypothesis that analysis of selected protein fractions from livers undergoing apoptosis will shed light on mechanisms that are involved in liver injury that might be amenable to intervention. Proteomic analysis of the major insoluble liver proteins after FasL exposure for 4-5 hours identified fibrinogen-c (FIB-c) dimers and FIB-c-containing high molecular mass complexes among the major insoluble proteins visible via Coomassie blue staining. Presence of the FIBc-containing products was confirmed using FIB-c-specific antibodies. The FIB-c-containing products partition selectively and quantitatively into the liver parenchyma after inducing apoptosis. Similar formation of FIB-c products occurs after acetaminophen administration. The observed intrahepatic IC raised the possibility that heparin therapy may ameliorate FasL-mediated liver injury. Notably, heparin administration in mice 4 hours before or up to 2 hours after FasL injection resulted in a dramatic reduction of liver injury-including liver hemorrhage, serum alanine
Who reads Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: Heparin prevents and treats liver damage?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Sujith V. W. Weerasinghe; David S. Moons; Peter J. Altshuler; Yatrik M. Shah; M. Bishr Omary
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)