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Prophylactic breast irradiation with a single dose of electron beam radiotherapy (10 Gy) significantly reduces the incidence of bicalutamide-induced gynecomastia by Christopher J. Tyrrell; Heather Payne; Teuvo L.J. Tammela; August Bakke; Pär Lodding; Louis Goedhals; Peter Van Erps; Tom Boon; Cees Van De Beek; Swen-Olof Andersson; Tom Morris; Kevin Carroll is a Medicine article available to read on EtoBox.

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Purpose: To evaluate the efficacy and tolerability of prophylactic breast irradiation in reducing the incidence and severity of bicalutamide-induced gynecomastia and breast pain. Methods and Materials: In all, 106 men with prostate cancer (T1b-T4/Nx/M0) and no current gynecomastia/ breast pain were enrolled in this randomized, sham-controlled, double-blind, parallel-group multicenter trial. Patients received either a single dose of electron beam radiotherapy (10 Gy) or sham radiotherapy. Bicalutamide (Casodex) 150 mg/day was administered for 12 months from the day of radiotherapy. Every 3 months, patients underwent physical examination and questioning about gynecomastia and breast pain. Results: The incidence of investigator-assessed gynecomastia was significantly lower with radiotherapy vs. sham radiotherapy (52% vs. 85%; odds ratio [OR], 0.13; 95% confidence interval [CI], 0.04, 0.38; p 5 cm gynecomastia (measured by calipers; 11.5% vs. 50.0% for sham radiotherapy), and fewer cases were moderate-to-severe in intensity (21% vs. 48%). Similar proportions of radiotherapy and sham radiotherapy patients experienced breast pain (83% vs. 91%; OR, 0.25; 95% CI, 0.05, 1.27; p ‫؍‬ 0.221);

Who reads Prophylactic breast irradiation with a single dose of electron beam radiotherapy (10 Gy) significantly reduces the incidence of bicalutamide-induced gynecomastia?

Author

Christopher J. Tyrrell; Heather Payne; Teuvo L.J. Tammela; August Bakke; Pär Lodding; Louis Goedhals; Peter Van Erps; Tom Boon; Cees Van De Beek; Swen-Olof Andersson; Tom Morris; Kevin Carroll

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2004

Language

EN

Field

Medicine (Health Sciences)