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Can I read GPER induces mitochondrial fission through p44/42 MAPK - Drp1 pathway in breast cancer cells on EtoBox?
GPER induces mitochondrial fission through p44/42 MAPK - Drp1 pathway in breast cancer cells by Pothuganti Rekha; Anshu Gupta; Kalali Sridivya Goud; Bidisha Biswas; Subhashith Bhattar; Gangipangi Vijayakumar; Sudhagar Selvaraju is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is GPER induces mitochondrial fission through p44/42 MAPK - Drp1 pathway in breast cancer cells about?
Understanding GPER biology in breast cancer is rather limited in compassion to the classic estrogen receptors. Mitochondrial dynamics play a critical role in determining cell survival and death under various microenvironmental conditions. We present evidence that GPER-induce mitochondrial fission in breast cancer cells. GPER mediated mitochondrial fission through activating Drp1 by phosphorylating S616 residue and down-regulates fusion proteins Mfn1 and Mfn2 levels. GPER-induced Drp1 activation mediated by p44/42 MAPK and inhibition of this signalling axis completely reverse the mitochondrial fission induced by GPER. Further, mitochondrial fission is required for GPER-induced cell death in breast cancer cells. To conclude, GPER induces mitochondrial fission through p44/42 MAPK - Drp1 signalling, and mitochondrial fission is critical for GPER-induced cell death in breast cancer cells. General significance First time we report GPER's role in mitochondrial dynamics in cancer cells. Mitochondrial dynamics play a critical role in cancer progression including tamoxifen resistance. Exploring a detailed mechanistic understanding of GPER signalling may help to design new therapy for advance
Who reads GPER induces mitochondrial fission through p44/42 MAPK - Drp1 pathway in breast cancer cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Pothuganti Rekha; Anshu Gupta; Kalali Sridivya Goud; Bidisha Biswas; Subhashith Bhattar; Gangipangi Vijayakumar; Sudhagar Selvaraju
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)