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Ethanol Extract of Mulberry Leaves Partially Restores the Composition of Intestinal Microbiota and Strengthens Liver Glycogen Fragility in Type 2 Diabetic Rats by Liu, Zhan-Zhong (author);Liu, Qing-Hua (author);Liu, Zhao (author);Tang, Jia-Wei (author);Chua, Eng-Guan (author);Li, Fen (author);Xiong, Xue-Song (author);Wang, Meng-Meng (author);Wen, Peng-Bo (author);Shi, Xin-Yi (author);Xi, Xiang-Yu (author);Zhang, Xiao (author);Wang, Liang (author) is a Medicine article available to read on EtoBox.

What is Ethanol Extract of Mulberry Leaves Partially Restores the Composition of Intestinal Microbiota and Strengthens Liver Glycogen Fragility in Type 2 Diabetic Rats about?

## Background Mulberry leaf as a traditional Chinese medicine is able to treat obesity, diabetes, and dyslipidemia. It is well known that diabetes leads to intestinal microbiota dysbiosis. It is also recently discovered that liver glycogen structure is impaired in diabetic animals. Since mulberry leaves are able to improve the diabetic conditions through reducing blood glucose level, it would be interesting to investigate whether they have any positive effects on intestinal microbiota and liver glycogen structure. ## Methods In this study, we first determined the bioactive components of ethanol extract of mulberry leaves via high-performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometry (LC/MS). Murine animal models were divided into three groups, normal Sprague-Dawley (SD) rats, high-fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetic rats, and HFD/STZ-induced rats administered with ethanol extract of mulberry leaves (200 mg/kg/day). Composition of intestinal microbiota was analyzed via metagenomics by sequencing the V3-V4 region of 16S rDNAs. Liver glycogen structure was characterized through size exclusion chromatography (SEC). Both Student

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Author
Liu, Zhan-Zhong (author);Liu, Qing-Hua (author);Liu, Zhao (author);Tang, Jia-Wei (author);Chua, Eng-Guan (author);Li, Fen (author);Xiong, Xue-Song (author);Wang, Meng-Meng (author);Wen, Peng-Bo (author);Shi, Xin-Yi (author);Xi, Xiang-Yu (author);Zhang, Xiao (author);Wang, Liang (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN
Field
Medicine (Health Sciences)

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