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Affinity Parameters of Amino Acid Derivative Binding to Molecularly Imprinted Nanospheres Consisting of Poly[(ethylene Glycol Dimethacrylate)-co-(methacrylic Acid)] by Mathias Lehmann; Melanie Dettling; Herwig Brunner; Günter E.M. Tovar is a Chemistry article available to read on EtoBox.

What is Affinity Parameters of Amino Acid Derivative Binding to Molecularly Imprinted Nanospheres Consisting of Poly[(ethylene Glycol Dimethacrylate)-co-(methacrylic Acid)] about?

The binding of L-Boc-phenylalanine anilide (BFA) and L-Boc-phenylalanine (phe) to molecularly imprinted and non-imprinted polymer nanoparticles consisting of poly[(ethylene glycol dimethacrylate)-co-(methacrylic acid)] has been investigated by adsorption experiments and mathematical modeling. The experimental isotherms have been mathematically adapted following the models of Freundlich, Langmuir, Langmuir-Freundlich, Bi-Langmuir, and extended Langmuir. The extended Langmuir model differentiated between specific and nonspecific binding of the ligand to the receptor nanoparticles and rendered excellent fitting of the experimental data. It delivered a thermodynamic and kinetic parameter set on the experimental association curves of L-BFA by L-BFA-imprinted nanospheres in suspension experiments with the equilibrium constant KD= 4.09 +/- 0.69 micromol L(-1) and the kinetic association rate constant Ka= 5.60 mL micromol(-1) min(-1).

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Author

Mathias Lehmann; Melanie Dettling; Herwig Brunner; Günter E.M. Tovar

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-376X)

Published

2004

Language

EN

Field

Chemistry (Physical Sciences)