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What is Methotrexate Resistance Mechanisms in Tumors about?

This document reviews the mechanisms of resistance to methotrexate (MTX) in human tumors, particularly focusing on acute lymphocytic leukemia and soft tissue sarcoma. Key resistance mechanisms include decreased drug uptake, increased dihydrofolate reductase (DHFR) activity, and impaired polyglutamylation. The findings highlight the complexity of MTX resistance and suggest avenues for developing new treatment strategies.

Author

esavaldez0910

Language

EN