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Can I read A New Hope for CD56^neg^CD16^pos^ NK Cells as Unconventional Cytotoxic Mediators: An Adaptation to Chronic Diseases on EtoBox?
A New Hope for CD56^neg^CD16^pos^ NK Cells as Unconventional Cytotoxic Mediators: An Adaptation to Chronic Diseases by Forconi, Catherine S.; Oduor, Cliff I.; Oluoch, Peter O.; Ong'echa, John M.; MÃ1⁄4nz, Christian; Bailey, Jeffrey A.; Moormann, Ann M. is a Medicine article available to read on EtoBox.
What is A New Hope for CD56^neg^CD16^pos^ NK Cells as Unconventional Cytotoxic Mediators: An Adaptation to Chronic Diseases about?
Natural Killer (NK) cells play an essential role in antiviral and anti-tumoral immune responses. In peripheral blood, NK cells are commonly classified into two major subsets: CD56^bright^CD16^neg^ and CD56^dim^CD16^pos^ despite the characterization of a CD56^neg^CD16^pos^ subset 25 years ago. Since then, several studies have described the prevalence of an CD56^neg^CD16^pos^ NK cell subset in viral non-controllers as the basis for their NK cell dysfunction. However, the mechanistic basis for their cytotoxic impairment is unclear. Recently, using a strict flow cytometry gating strategy to exclude monocytes, we reported an accumulation of CD56^neg^CD16^pos^ NK cells in __Plasmodium falciparum__ malaria-exposed children and pediatric cancer patients diagnosed with endemic Burkitt lymphoma (eBL). Here, we use live-sorted cells, histological staining, bulk RNA-sequencing and flow cytometry to confirm that this CD56^neg^CD16^pos^ NK cell subset has the same morphological features as the other NK cell subsets and a similar transcriptional profile compared to CD56^dim^CD16^pos^ NK cells with only 120 genes differentially expressed (fold change of 1.5, __p__ < 0.01 and FDR<0.05) out of 9235
Who reads A New Hope for CD56^neg^CD16^pos^ NK Cells as Unconventional Cytotoxic Mediators: An Adaptation to Chronic Diseases?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Forconi, Catherine S.; Oduor, Cliff I.; Oluoch, Peter O.; Ong'echa, John M.; MÃ1⁄4nz, Christian; Bailey, Jeffrey A.; Moormann, Ann M.
- Publisher
- Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2011- (ISSN 2235-2988)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)