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The document summarizes the pharmacokinetics and pharmacodynamics of proton pump inhibitors (PPIs). PPIs work by binding covalently to the H+,K+-ATPase enzyme in parietal cells, inhibiting gastric acid secretion. Several factors influence PPI effectiveness, including accumulation in parietal cells, metabolism rates, and binding stability. Though PPIs have similar core structures, their properties differ, with dexlansoprazole showing best gastric pH control. Overall, PPIs significantly improved treatment of

Author

HadiNugraha

Language

EN