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Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease by Pratishtha Chatterjee; Steve Pedrini; Nicholas J. Ashton; Michelle Tegg; Kathryn Goozee; Abhay K. Singh; Thomas K. Karikari; Joel Simrén; Eugeen Vanmechelen; Nicola J. Armstrong; Eugene Hone; Prita R. Asih; Kevin Taddei; Vincent Doré; Victor L. Villemagne; Hamid R. Sohrabi; Henrik Zetterberg; Colin L. Masters; Kaj Blennow; Ralph N. Martins is a Medicine article available to read on EtoBox.
What is Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease about?
## Abstract ## Introduction This study involved a parallel comparison of the diagnostic and longitudinal monitoring potential of plasma glial fibrillary acidic protein (GFAP), total tau (t‐tau), phosphorylated tau (p‐tau181 and p‐tau231), and neurofilament light (NFL) in preclinical Alzheimer's disease (AD). ## Methods Plasma proteins were measured using Simoa assays in cognitively unimpaired older adults (CU), with either absence (Aβ−) or presence (Aβ+) of brain amyloidosis. ## Results Plasma GFAP, t‐tau, p‐tau181, and p‐tau231 concentrations were higher in Aβ+ CU compared with Aβ− CU cross‐sectionally. GFAP had the highest effect size and area under the curve (AUC) in differentiating between Aβ+ and Aβ− CU; however, no statistically significant differences were observed between the AUCs of GFAP, p‐tau181, and p‐tau231, but all were significantly higher than the AUC of NFL, and the AUC of GFAP was higher than the AUC of t‐tau. The combination of a base model (BM), comprising the AD risk factors, age, sex, and apolipoprotein E gene (APOE) ε4 status with GFAP was observed to have a higher AUC (>90%) compared with the combination of BM with any of the other proteins investigated in t
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- Author
- Pratishtha Chatterjee; Steve Pedrini; Nicholas J. Ashton; Michelle Tegg; Kathryn Goozee; Abhay K. Singh; Thomas K. Karikari; Joel Simrén; Eugeen Vanmechelen; Nicola J. Armstrong; Eugene Hone; Prita R. Asih; Kevin Taddei; Vincent Doré; Victor L. Villemagne; Hamid R. Sohrabi; Henrik Zetterberg; Colin L. Masters; Kaj Blennow; Ralph N. Martins
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)