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Crucial role of linker portion in acridine-bearing oligonucleotides for highly efficient site-selective RNA scission by Yun Shi; Akinori Kuzuya; Kenzo Machida; Makoto Komiyama is a Chemistry article available to read on EtoBox.

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Through a series of linkers, 9-amino-2-methoxy-6-nitroacridine and 9-amino-6-chloro-2-methoxyacridine were tethered to the middle of oligonucleotide, and the abilities of these conjugates for site-selective activation of RNA (inducing site-selective scission by Lu(III)) were compared. The RNA-activating ability was strongly dependent on the structures of both acridine and linker. By tethering 9-amino-2-methoxy-6-nitroacridine with a rigid and chiral linker, derived from L L -threoninol, quite fast siteselective RNA scission was accomplished.

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Author

Yun Shi; Akinori Kuzuya; Kenzo Machida; Makoto Komiyama

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)

Published

2004

Language

EN

Field

Chemistry (Physical Sciences)