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Transdermal Iontophoresis of 5-Fluorouracil Combined with Electroporation and Laser Treatment by Jia-You Fang; Chi-Feng Hung; Yi-Ping Fang; Te-Fu Chan is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Transdermal Iontophoresis of 5-Fluorouracil Combined with Electroporation and Laser Treatment about?

The influence of iontophoresis and other physical enhancement methods such as electroporation and erbium:yttrium-aluminumgarnet (YAG) laser on the skin permeation of 5-fluorouracil (5-FU) was examined. Iontophoresis increased the in vitro transdermal transport of both the anionic and non-ionic forms of 5-FU. A combination of electroporation pretreatment and subsequent iontophoresis resulted in a higher permeation of 5-FU than either technique alone. It appeared that electroporation treatment exerted a disruptive influence on the stratum corneum (SC). The SC layers in the skin were partly ablated by the laser, resulting in a great enhancement effect on the skin permeation of 5-FU. Application of iontophoresis further increased the drug permeation across laser-pretreated skin. The laser was consistently the most potent technique to enhance 5-FU delivery among the physical enhancement methods examined in this study.

Who reads Transdermal Iontophoresis of 5-Fluorouracil Combined with Electroporation and Laser Treatment?

Author

Jia-You Fang; Chi-Feng Hung; Yi-Ping Fang; Te-Fu Chan

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2004

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)