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Sensitivity of Cultured Human Pancreatic Carcinoma Cells to Dihydroxyanthracenedione by George Fountzilas; Howard Gratzner; Lori O. Lim; Adel A. Yunis is a Medicine article available to read on EtoBox.

What is Sensitivity of Cultured Human Pancreatic Carcinoma Cells to Dihydroxyanthracenedione about?

We tested the effectiveness of dihydroxyanthracenedione (DHAD) on cell growth of two human pancreatic carcinoma cell lines MIA PaCa-2 and PANC-1. At the level of ID,,, the drug was almost equally effective against both cell lines. When the time exposure of MIA PaCa-2 cells to the drug was increased from I h to continuous exposure for 5 days, the ID,, was decreased about three-fold only (I .4 X lo4 M and 4 X lo4 M respectively). At the level of ID,, also the difference between 6 h exposure and continuous exposure for 5 days was minimal. In equimolar concentrations and with I h exposure, DHAD was more effective against MIA PaCa-2 cells than other chemotherapeutic agents including adriamycin, mitomycin-C, 5-FU, vincristine, vindesine. vinblastine, VP-16-2 13, bleomycin, cis-platinum, asparaginase and acivicin. In concentrations of 5 X lo-' M, DHAD caused about 40 % inhibition of "C-thymidine incorporation of MIA PaCa-2 cells. Treatment of MIA PaCa-2 cells with the ID, of DHAD for I h caused retardation of cellular traverse, with the major effect appearing to be in G2+M phase of the cycle. From these data DHAD appears to be a potent drug against human pancreatic carcinoma in V i m .

Who reads Sensitivity of Cultured Human Pancreatic Carcinoma Cells to Dihydroxyanthracenedione?

Author

George Fountzilas; Howard Gratzner; Lori O. Lim; Adel A. Yunis

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1984

Language

EN

Field

Medicine (Health Sciences)