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ARHGEF7 ( Î2 -PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function by Matsuda, Jun; Maier, Mirela; Aoudjit, Lamine; Baldwin, Cindy; Takano, Tomoko is a Medicine article available to read on EtoBox.

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## Significance Statement Dysregulation of Cdc42 and other members of the Rho family of small GTPases in podocytes contributes to the pathogenesis of proteinuria. However, the upstream regulatory mechanisms for Cdc42 activity in podocytes are largely unknown. The authors identified ARHGEF7 (commonly known as β-PIX) as a predominant guanine nucleotide exchange factor and activator of Cdc42 in podocytes. They also demonstrated that β-PIX is required for the maintenance of podocyte architecture and glomerular function via Cdc42 and its downstream effects on Yes-associated protein (YAP) activity. Elucidating the precise details of how numerous regulatory proteins maintain the delicate balance of Rho GTPases in podocytes will be essential in understanding the pathogenesis of proteinuric glomerular diseases and identifying therapeutic targets. ## Background Previous studies showed that Cdc42, a member of the prototypical Rho family of small GTPases and a regulator of the actin cytoskeleton, is critical for the normal development and health of podocytes. However, upstream regulatory mechanisms for Cdc42 activity in podocytes are largely unknown. ## Methods We used a proximity-based ligati

Who reads ARHGEF7 ( Î2 -PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function?

Author

Matsuda, Jun; Maier, Mirela; Aoudjit, Lamine; Baldwin, Cindy; Takano, Tomoko

Publisher

Lippincott Williams and Wilkins; American Society of Nephrology; American Society of Nephrology (ASN); Ovid Technologies (Wolters Kluwer Health) (ISSN 1046-6673)

Published

2020

Language

EN

Field

Medicine (Health Sciences)