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Effects of Exercise in Patients With Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis by Lijiao Meng; Xiaoxiao Li; Cheng Li; Raymond C.C. Tsang; Yi Chen; Yanlei Ge; Qiang Gao is a Medicine article available to read on EtoBox.

What is Effects of Exercise in Patients With Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis about?

## Objective: The aim of this study was to systematically review the efficacy and safety of exercise in patients with amyotrophic lateral sclerosis (als). ## Design: Randomized controlled trials of exercises for als were searched in pubmed, embase, web of science, cochrane library, china biology medicine database, china national knowledge internet, vip database, and wanfang database. the primary outcomes were functional ability, pulmonary function, and quality of life. the secondary outcomes were muscle strength, fatigue and adverse events. meta-analysis was performed using the revman version 5.3 software. ## Results: Seven randomized controlled trials including 322 patients with als met the inclusion criteria. meta-analysis showed that the functional scores at long-term (standardized means difference, 0.47; 95% confidence interval, 0.08-0.86; p = 0.02) and forced vital capacity percentage predicted (mean difference, 1.71; 95% confidence interval, 0.10-3.31; p = 0.04) of patients with als in the exercise group were significantly higher than those in the group of no exercise or usual care. no significant difference was observed in muscle strength and quality of life. endurance or ae

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Author

Lijiao Meng; Xiaoxiao Li; Cheng Li; Raymond C.C. Tsang; Yi Chen; Yanlei Ge; Qiang Gao

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2020

Language

EN

Field

Medicine (Health Sciences)