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Stem cell factor (SCF) is a recently identified homodimeric hematopoietic growth factor that acts to stimulate the proliferation of early hematopoietic stem cells.1 Comparative analysis of the SCF sequence has revealed that it is similar to a number of other growth factors such as GM-CSF, growth hormone, IL-4 and M-CSF for which recent structural results have shown a distinctive 4 *-helix folding motif. We report here preliminary crystallographic studies enroute to obtaining more detailed structural informa

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