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Analysis, Characterization, and Purification: Requirements for Toxicological Evaluation of 1,4-Dithiane by Harold C. Thompson Jr.; William M. Blakemore; Daniel M. Nestorick; James P. Freeman; Dwight W. Miller is a Chemistry article available to read on EtoBox.

What is Analysis, Characterization, and Purification: Requirements for Toxicological Evaluation of 1,4-Dithiane about?

1 ,CDithiane is an organo-sulfur chemical associated with production and storage of munitions. Toxicological evaluation of this chemical was scheduled in rats because of the paucity of such information. Prerequisite for the evaluation was the development of gas chromatographic procedures using flame ionization detection to determine the purity of the test chemical and to certify the concentration and stability of the chemical in the dosage form, sesame oil. Mass and nuclear magnetic resonance spectrometry procedures are described for assessing the structural character and purity of the test chemical. A procedure for the purification of the test chemical and data concerning its solubility in various solvents are also presented.

Who reads Analysis, Characterization, and Purification: Requirements for Toxicological Evaluation of 1,4-Dithiane?

Author

Harold C. Thompson Jr.; William M. Blakemore; Daniel M. Nestorick; James P. Freeman; Dwight W. Miller

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

1989

Language

EN

Field

Chemistry (Physical Sciences)