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Mirtazapine and Paroxetine: a Drug-drug Interaction Study in Healthy Subjects by F. J. L. Ruwe; R. A. Smulders; H. J. Kleijn; H. L. A. Hartmans; J. M. A. Sitsen is a Medicine article available to read on EtoBox.

What is Mirtazapine and Paroxetine: a Drug-drug Interaction Study in Healthy Subjects about?

Paroxetine inhibits cytochrome P(450) 2D6, which is involved in the metabolism of mirtazapine. The possible drug-drug interaction between two pharmacologically distinct antidepressants, mirtazapine and paroxetine, has been investigated in a randomized, three-way crossover study in 24 healthy male and female subjects. After a titration phase of 3 days, each subject received single daily doses of 30 mg mirtazapine, 40 mg paroxetine or the combination for 6 days. Assessments included serial blood sampling for pharmacokinetics at steady state, cognitive testing using the test battery of CDR Ltd, a visual analogue mood rating scale (Bond and Lader) and the Leeds Sleep Evaluation Questionnaire. Paroxetine inhibits the metabolism of mirtazapine, as shown by increases of approximately 17% and 25% of the 24 h AUC's of mirtazapine and its demethyl metabolite, respectively. Mirtazapine did not alter the pharmacokinetics of paroxetine. The combined administration of mirtazapine and paroxetine probably does not alter cognitive functioning or result in major changes on the visual analogue mood rating scale and Sleep Evaluation Questionnaire, compared with the administration of either drug alone.

Who reads Mirtazapine and Paroxetine: a Drug-drug Interaction Study in Healthy Subjects?

Author

F. J. L. Ruwe; R. A. Smulders; H. J. Kleijn; H. L. A. Hartmans; J. M. A. Sitsen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-6222)

Published

2002

Language

EN

Field

Medicine (Health Sciences)