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Can I read Coating of Dacron vascular grafts with an ionic polyurethane: a novel sealant with protein binding properties on EtoBox?
Coating of Dacron vascular grafts with an ionic polyurethane: a novel sealant with protein binding properties by Matthew D. Phaneuf; Donald J. Dempsey; Martin J. Bide; William C. Quist; Frank W. LoGerfo is a Engineering article available to read on EtoBox.
What is Coating of Dacron vascular grafts with an ionic polyurethane: a novel sealant with protein binding properties about?
The purpose of this study was to develop a novel sealant that would seal prosthetic vascular graft interstices and be accessible for protein binding. Crimped knitted Dacron vascular grafts were cleaned (CNTRL) and hydrolyzed in boiling sodium hydroxide (HYD). These HYD grafts were sealed using an 11% solids solution of a polyether-based urethane with carboxylic acid groups (PEU-D) via a novel technique that employs both trans-wall and luminal perfusion. Carboxylic acid content, determined via methylene blue dye uptake, was 2.3-and 4.2-fold greater in PEU-D segments (1.0$0.27 nmol/mg) as compared to HYD and CNTRL segments, respectively. Water permeation through PEU-D graft (1.1$2 ml/cm min\) was comparable to collagen-impregnated Dacron (9.8$10 ml/cm min\). Non-speci"c I-albumin (I-Alb) binding to PEU-D segments (18$3 ng/mg) was signi"cantly lower than HYD and CNTRL segments. I-Alb linkage to PEU-D using the crosslinker EDC resulted in 5.7-fold greater binding (103$2 ng/mg) than non-speci"c PEU-D controls. However, covalent linkage of I-Alb to PEU-D was 4.9-and 5.9-fold less than CNTRL and HYD segments with EDC, respectively. Thus, ionic polyurethane can be applied to a pre-formed v
Who reads Coating of Dacron vascular grafts with an ionic polyurethane: a novel sealant with protein binding properties?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Matthew D. Phaneuf; Donald J. Dempsey; Martin J. Bide; William C. Quist; Frank W. LoGerfo
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)
- Published
- 2001
- Language
- EN
- Field
- Engineering (Physical Sciences)