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Familial Gastric Cancer – Aetiology and Pathogenesis by Miriam Barber; Rebecca C. Fitzgerald; Carlos Caldas is a Medicine article available to read on EtoBox.

What is Familial Gastric Cancer – Aetiology and Pathogenesis about?

Gastric cancer is the second most common cause of cancer death worldwide. It is estimated that 5e10% of gastric cancer cases have a familial association; however, knowledge concerning the genetic predisposition to familial gastric cancer is currently limited. In this chapter we discuss what is known about the aetiology and pathogenesis of both the diffuse and intestinal forms of familial gastric cancer. We focus particularly on hereditary diffuse gastric cancer because the discovery of germ-line E-cadherin mutations in a number of affected families has opened the prospect of identifying gene carriers, with implications for clinical management. The interplay of other conventional risk factors, such as Helicobacter pylori infection, with genetic factors is also discussed. It is hoped that understanding the genetic basis for familial gastric cancer will facilitate the development of clinically useful screening and preventative procedures.

Who reads Familial Gastric Cancer – Aetiology and Pathogenesis?

Author

Miriam Barber; Rebecca C. Fitzgerald; Carlos Caldas

Publisher

Elsevier Science; Elsevier ; Bailliere Tindall Ltd; Elsevier BV (ISSN 1521-6918)

Published

2006

Language

EN

Field

Medicine (Health Sciences)