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Can I read Protein structure-based evaluation of missense variants: Resources, challenges and future directions on EtoBox?
Protein structure-based evaluation of missense variants: Resources, challenges and future directions by Alessia David; Michael J.E. Sternberg is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Protein structure-based evaluation of missense variants: Resources, challenges and future directions about?
We provide an overview of the methods that can be used for protein structure-based evaluation of missense variants. The algorithms can be broadly divided into those that calculate the difference in free energy (ΔΔG) between the wild type and variant structures and those that use structural features to predict the damaging effect of a variant without providing a ΔΔG. A wide range of machine learning approaches have been employed to develop those algorithms. We also discuss challenges and opportunities for variant interpretation in view of the recent breakthrough in three-dimensional structural modelling using deep learning.
Who reads Protein structure-based evaluation of missense variants: Resources, challenges and future directions?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Alessia David; Michael J.E. Sternberg
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)