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VEGF functionalization of suture tape results in decreased graft inflammatory and catabolic response in a rabbit model of ACL reconstruction by Mario Hevesi; Carlo A. Paggi; Joao F. Crispim; Wouter van Genechten; Janet M. Denbeigh; Nicholas J. Olson; Amel Dudakovic; Andre J. van Wijnen; Aaron J. Krych; Daniel B.F. Saris is a Medicine article available to read on EtoBox.
What is VEGF functionalization of suture tape results in decreased graft inflammatory and catabolic response in a rabbit model of ACL reconstruction about?
Introduction Improving ligament reconstruction biology may potentially be achieved through capturing autologous circulating factors such as vascular endothelial growth factor (VEGF) using commercially available biomaterials. Objectives To evaluate anterior cruciate ligament reconstruction (ACLR) using a VEGF functionalized suture tape in a rabbit model of ACLR with a semitendinosus autograft. Methods VEGF-binding peptides were covalently bonded to polyethylene suture tape (ST) to generate functionalized constructs. Forty-six female New Zealand white rabbit ACLs were reconstructed with semitendinosus hamstring autograft (n = 6), hamstring + ST (n = 16), hamstring + scrambled peptide ST (n = 17), and hamstring + VEGF-functionalized ST (n = 17). Healing was evaluated at 2to 4 weeks using PCR, RNA sequencing, micro CT, histology, and biomechanical testing. Results All rabbits successfully underwent ACLR, with no adverse events. ACLR with VEGF ST demonstrated significant decreases in inflammatory response (CD14, CD163), catabolism (MMP1, MMP3), and apoptosis (TNFSF10, Caspase-10) markers as compared to nonfunctionalized ST (P ≤ .04). μCT demonstrated similar bone tunnel mineral density
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- Author
- Mario Hevesi; Carlo A. Paggi; Joao F. Crispim; Wouter van Genechten; Janet M. Denbeigh; Nicholas J. Olson; Amel Dudakovic; Andre J. van Wijnen; Aaron J. Krych; Daniel B.F. Saris
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)