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Supplementation with pumpkin seed oil improves plasma lipid profile and cardiovascular outcomes of female non-ovariectomized and ovariectomized Sprague-Dawley rats by M. Gossell-Williams; K. Lyttle; T. Clarke; M. Gardner; O. Simon is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Pumpkin (__Cucurbita species__) seed oil (PSO) is a rich source of phytoestrogens and the aim of this study was to examine the effect of PSO supplementation on the total cholesterol (TC), low density lipoprotein cholesterol (LDL‐C), triglycerides, high density lipoprotein cholesterol (HDL‐C), systolic and diastolic blood pressure in non‐ovariectomized and ovariectomized Sprague‐Dawley rats. Female rats weighing 220–300 g were divided into non‐ovariectomized rats for supplementation with corn oil (control CO; __n__ = 6) or PSO (control PSO; __n__ = 5) and ovariectomized rats for supplementation with corn oil (OVX/CO; __n__ = 6) or PSO (OVX/PSO; __n__ = 5) for 5 days per week for 12 weeks (corn oil 40 mg/kg or PSO 40 mg/kg given orally). Systolic and diastolic blood pressures were measured weekly. Blood was collected at the end of the period for plasma lipid assays. Control PSO had lower TC, LDL–C, triglycerides and higher HDL‐C than the control CO. The OVX/CO had higher TC, LDL–C, triglycerides and lower HDL‐C than the control CO and these changes were prevented in the OVX/PSO rats. PSO supplementation also resulted in lower systolic and diastolic blood pressures in both

Who reads Supplementation with pumpkin seed oil improves plasma lipid profile and cardiovascular outcomes of female non-ovariectomized and ovariectomized Sprague-Dawley rats?

Author

M. Gossell-Williams; K. Lyttle; T. Clarke; M. Gardner; O. Simon

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)