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The article discusses a novel method for in vivo site-specific engineering of T cells to enhance their therapeutic potential, particularly in cancer treatment. By utilizing a two-vector system with CRISPR-Cas9 and adeno-associated viruses, the researchers achieved stable integration of CAR transgenes into T cell-specific loci, generating therapeutic levels of CAR T cells in humanized mouse models. This approach addresses the limitations of traditional ex vivo CAR T cell manufacturing, offering a more effici

Author

gabrielyosmith

Language

EN