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Can I read Multi-omics Microsampling for the Profiling of Lifestyle-associated Changes in Health on EtoBox?
Multi-omics Microsampling for the Profiling of Lifestyle-associated Changes in Health by Xiaotao Shen; Ryan Kellogg; Daniel J. Panyard; Nasim Bararpour; Kevin Erazo Castillo; Brittany Lee-McMullen; Alireza Delfarah; Jessalyn Ubellacker; Sara Ahadi; Yael Rosenberg-Hasson; Ariel Ganz; Kévin Contrepois; Basil Michael; Ian Simms; Chuchu Wang; Daniel Hornburg; Michael P. Snyder is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Multi-omics Microsampling for the Profiling of Lifestyle-associated Changes in Health about?
## Abstract Current healthcare practices are reactive and use limited physiological and clinical information, often collected months or years apart. Moreover, the discovery and profiling of blood biomarkers in clinical and research settings are constrained by geographical barriers, the cost and inconvenience of in-clinic venepuncture, low sampling frequency and the low depth of molecular measurements. Here we describe a strategy for the frequent capture and analysis of thousands of metabolites, lipids, cytokines and proteins in 10 μl of blood alongside physiological information from wearable sensors. We show the advantages of such frequent and dense multi-omics microsampling in two applications: the assessment of the reactions to a complex mixture of dietary interventions, to discover individualized inflammatory and metabolic responses; and deep individualized profiling, to reveal large-scale molecular fluctuations as well as thousands of molecular relationships associated with intra-day physiological variations (in heart rate, for example) and with the levels of clinical biomarkers (specifically, glucose and cortisol) and of physical activity. Combining wearables and multi-omics m
Who reads Multi-omics Microsampling for the Profiling of Lifestyle-associated Changes in Health?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Xiaotao Shen; Ryan Kellogg; Daniel J. Panyard; Nasim Bararpour; Kevin Erazo Castillo; Brittany Lee-McMullen; Alireza Delfarah; Jessalyn Ubellacker; Sara Ahadi; Yael Rosenberg-Hasson; Ariel Ganz; Kévin Contrepois; Basil Michael; Ian Simms; Chuchu Wang; Daniel Hornburg; Michael P. Snyder
- Publisher
- Nature Publishing Group UK
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)