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A Novel Blastomere Morphology Marker In Cleavage Stage Embryos Strongly Predicts Blastocyst Development And Pregnancy Outcome by Biswanath Ghoshdastidar; Sudarsan Ghosh Dastidar is a Medicine article available to read on EtoBox.

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SR, the latter group of patients are included but historically do not exceed 5% of all PGT cases and, therefore, only unlikely affect here reported outcomes.RESULTS: A total of 43,841 IVF cycles were compared between the low and high PGT-A utilization groups. Of these, 15,599 were in women <35 years with low 0-19.9% PGT-A cycles and 3,399 with high 80-100% PGT-A utilization. The live birth rates significantly declined with the higher utilization (45.6% high utilization vs 50.6% low utilization, p<0.0001, CI 44.0-47.4% and CI 49.8-51.4%, respectively). At older ages, 35-37; 38-40; 41-42 and R43 years, no differences in LBRs rates were observed between low and high PGT-A utilization. For all ages combined, the live birth rates significantly declined with the higher PGT-A utilization (29.8% high utilization vs 36.8% low utilization, p<0.0001, CI 28.9-30.7% and 36.3-37.3% respectively).CONCLUSIONS: These data offer further evidence that high utilization of PGT-A at no age improves live birth rates. Moreover, centers that utilize PGT-A indiscriminately in 80-100% of IVF cycles in their youngest patients <35 years, will affect their live birth chances adversely.IMPACT STATEMENT: At a tim

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Author

Biswanath Ghoshdastidar; Sudarsan Ghosh Dastidar

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)